منابع مشابه
Select: Stem Cell Reprogramming
Researchers have long suspected that cancer cells and stem cells share a core molecular signature, but this commonality remains incompletely understood. By examining microRNA (miRNA) expression patterns in multiple types of cancer cells and stem cells, Neveu et al. (2010) have now developed the miRMap, a tool that facilitates quantitative examination of the molecular hallmarks associated with a...
متن کاملDirect reprogramming of stem cell properties in colon cancer cells by CD44.
Cancer progression is commonly segregated into processes of primary tumour growth and secondary metastasis. Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumour growth in cancer. However, the role of CSCs in cancer metastasis is unclear. In this study, we found that the C terminus of CD44 contributes to sphere formation and survival ...
متن کاملRestoring totipotency through epigenetic reprogramming.
Epigenetic modifications are implicated in the maintenance and regulation of transcriptional memory by marking genes that were previously transcribed to facilitate transmission of these expression patterns through cell division. During germline specification and maintenance, extensive epigenetic modifications are acquired. Yet somehow at fertilization, the fusion of the highly differentiated sp...
متن کاملDirect reprogramming into desired cell types by defined factors.
In the field of developmental biology, the concept that cells, once terminally differentiated, are fixed in their cell fate was long believed to be true. However, Dr. Gurdon and colleagues challenged this fundamental doctrine and demonstrated that cellular reprogramming and cell fate conversion are possible by somatic nuclear transfer and cell fusion. The Weintraub laboratory discovered in the ...
متن کاملRestoring balance to liver stem cell research.
This month’s report from Saji et al., entitled ‘Basic fibroblast growth factor promotes the trans-differentiation of mouse bone marrow cells into hepatic lineage cells via multiple liver-enriched transcription factors’ [1], is one of a handful of recent papers helping to restore balance to the contentious field of adult stem cell research in general and, more specifically, to investigations of ...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2012
ISSN: 1934-5909
DOI: 10.1016/j.stem.2012.04.010